Cisco Secure Endpoint vs ThreatLocker (2026)
Our verdict
Cisco Secure Endpoint vs ThreatLocker: on our data-weighted scoring, ThreatLocker edges ahead (8.7 vs 7.9/10). Cisco Secure Endpoint starts at Custom quote and is best for cisco-centric enterprises wanting integrated edr; ThreatLocker starts at Custom quote and is best for msps wanting zero trust allowlisting and ringfencing. Choose ThreatLocker for the stronger overall track record; consider Cisco Secure Endpoint if its pricing model or fit matches your environment better. Side-by-side table below.
| Cisco Secure Endpoint | ThreatLocker | |
|---|---|---|
| Starting price | Custom quote | Custom quote |
| Pricing model | quote | quote |
| Free trial / tier | yes | 30 days |
| Best for | Cisco-centric enterprises wanting integrated EDR | MSPs wanting Zero Trust allowlisting and ringfencing |
| Deployment | Cloud | Cloud |
| G2 rating | 4.4/5 (150) | 4.8/5 (250) |
| Capterra rating | — | — |
| Our score | 7.9/10 | 8.7/10 |
Cisco Secure Endpoint
Pros
- Talos threat intelligence
- Integrates with Cisco stack
- Solid detection
Cons
- Best within Cisco ecosystem
- Quote pricing
- Heavier admin
Affiliate link: Cisco Secure Endpoint may pay us a commission if you sign up through this link. It never affects our data-driven ranking.
ThreatLocker
Pros
- Powerful Zero Trust controls
- Excellent support
- Strong MSP fit
Cons
- Allowlisting requires ongoing tuning
- Quote pricing
- Different model than AV/EDR
Affiliate link: ThreatLocker may pay us a commission if you sign up through this link. It never affects our data-driven ranking.
Choose Cisco Secure Endpoint if…
You need cisco-centric enterprises wanting integrated edr. See the Cisco Secure Endpoint pricing and review.
Choose ThreatLocker if…
You need msps wanting zero trust allowlisting and ringfencing. See the ThreatLocker pricing and review.
In depth
Pricing: ThreatLocker vs Cisco Secure Endpoint
ThreatLocker bills on a quote model from Custom quote (30 days trial), while Cisco Secure Endpoint uses a quote model from Custom quote (yes trial). Because the models differ, the cheaper option flips depending on your fleet size — model both at your seat/endpoint count.
Features & deployment
ThreatLocker ships 5 headline capabilities (Application allowlisting, Ringfencing, Storage control, Elevation control) and deploys Cloud. Cisco Secure Endpoint ships 4 (EDR with Talos intel, SecureX/XDR integration, Threat hunting, Sandboxing), deploying Cloud.
Ratings & verdict
ThreatLocker holds 4.8/5 (250 G2 reviews); Cisco Secure Endpoint holds 4.4/5 (150 G2 reviews). On our data-weighted score, ThreatLocker edges ahead (8.7 vs 7.9/10). Pick Cisco Secure Endpoint instead when cisco-centric enterprises wanting integrated edr. See ThreatLocker alternatives or Cisco Secure Endpoint alternatives.
Frequently asked questions
- Cisco Secure Endpoint vs ThreatLocker: which is better?
- Cisco Secure Endpoint vs ThreatLocker: on our data-weighted scoring, ThreatLocker edges ahead (8.7 vs 7.9/10). Cisco Secure Endpoint starts at Custom quote and is best for cisco-centric enterprises wanting integrated edr; ThreatLocker starts at Custom quote and is best for msps wanting zero trust allowlisting and ringfencing.
- Is Cisco Secure Endpoint cheaper than ThreatLocker?
- Cisco Secure Endpoint starts at Custom quote and ThreatLocker starts at Custom quote (see the pricing rows for models and limits).